Victorian skipper Kristen Beams won the toss and elected to bowl on a sunny afternoon at Manuka Oval.
Katie Mack and Hayley Jensen opened the batting for the ACT, combining for 42 runs before Jensen was caught mid on by Tayla Vlaeminck giving Molly Strano the first wicket of the afternoon.
It was the breakthrough that Victoria needed, with the wickets of Kapp (4) and Mack (22) falling shortly after, leaving the ACT 3-56.
Erin Osborne and Angela Reakes looked like slowing down the attack, but an Osborne shot to mid off was caught by Georgia Wareham giving Alana King her first wicket.
It was another domino effect, with Reakes (13) and Burns (13) joining the skipper on the sideline not long later. The partnership of van Niekerk and Claire Koski, 69, put the Meteors innings back on track and helped set up a respectable total of 203 for the Spirit to chase.
Marizanne Kapp was given the task to open the bowling for the ACT, not surprising given her status as the no.1 ranked female bowler in the world.
However it was her South African team mate van Niekerk who broke up the opening partnership of Victoria's Molineux and Blows, dismissing Blows (12) and then Molineux (50) just four overs later.
Left arm orthodox bowler Sam Bates did a fantastic job in the middle of the innings to slow down the Spirits run rate, and a spectatular caught and bowled to dismiss Emma Inglis (20) was what the Meteors needed.
A strong piece of fielding from Angela Reakes ran out Georgia Wareham and it was all downhill from there for the Victorians.
Wickets from van Niekerk (3-31), Hancock (2-30) and Bates (1-20) left Victoria 7-173 after fifty overs and the ACT with a 30-point win.
With the most runs and most wickets, van Niekerk was the easy selection for the Player of the Match.
The Meteors will play the Queensland Fire on Sunday, 10am, at Manuka Oval. Entry is free.